1-Amino-2-propanol → HCID 69482038, compound

Participants

Reaction Steps

In a similar manner to that described in example 196, from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(3-hydroxypropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (60 mg, 0.15mmol) and 1-amino-2-propanol (0.05 mL) was prepared 7-[(4-fluorophenyl)methyl]-4-hydroxy-N-(2-hydroxypropyl)-1-(3-hydroxypropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide (22 mg, 34% yield) as a yellow solid after purification by reverse phase HPLC. 1H NMR (CDCl3) δ 10.27 (br s, 1 H), 8.49 (s, 1 H), 7.52 (s, 1 H), 7.14-7.10 (m, 2 H), 6.99-6.94 (m, 2 H), 4.26 (m, 2 H), 4.09 (s, 2 H), 3.95 (m, 1 H), 3.55-3.47 (m, 3 H), 3.29 (m, 1 H), 1.79 (m, 2 H), 1.19 (d, J=6 Hz, 3 H); MS m/z 430 (M+1).

Provenance & Evidence