2-Methoxyethylamine → HCID 69482704, compound

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Reaction Steps

This compound was prepared from ethyl 1-[3-(2,5-dioxo-1-pyrrolidinyl)propyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 2-methoxyethylamine employing methods similar to those described in Example 202 and was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ 10.27 (s, 1 H), 8.56 (s, 1 H), 7.34 (s, 1 H), 7.19 (dd, J=8.4, 5.4 Hz, 2 H), 7.04 (t, J=8.6 Hz, 2 H), 4.18-4.12 (m, 4 H), 3.64 (m, 2 H), 3.61-3.57 (m, 4 H), 3.42 (s, 3 H), 2.73 (s, 4 H), 1.91 (m, 2 H); HRMS C26H27FN4O6 (M+H)+ calcd 511.1915, found 511.1988.

Provenance & Evidence