Methylamine → HCID 69482046, compound

Participants

Reaction Steps

This compound was prepared from ethyl 1-{2-[acetyl(methyl)amino]ethyl}-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and methylamine in ethanol using methods similar to Example 574: step 2 to provide an off-white solid: 1H NMR (400 MHz, DMSO-d6 (90° C.) δ ppm 1.80-1.87 (m, 3 H), 2.95 (d, J=4.94 Hz, 6 H), 3.53 (t, J=6.79 Hz, 2 H), 4.18 (s, 2 H), 4.36 (s, 2 H), 7.12 (t, J=8.44 Hz, 2 H), 7.35-7.40 (m, 2 H), 8.05 (s, 1 H), 8.54 (s, 1 H), 10.07 (s, 1 H), 17.05 (br. s., 1 H); ES+ MS: 427 (M+H+).

Provenance & Evidence