4-Amino-1-butanol → HCID 86612793, compound

HRID 2364459Notes

Reaction equation

HRID 2364459 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13]([OH:40])=[C:14]([C:35](OCC)=[O:36])[C:15](=[O:34])[N:16]3[CH2:19][CH2:20][CH2:21][N:22]([CH3:33])[C:23]([O:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[O:24])=[N:11][CH:10]=2)=[CH:4][CH:3]=1.[NH2:41][CH2:42][CH2:43][CH2:44][CH2:45][OH:46]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13]([OH:40])=[C:14]([C:35]([NH:41][CH2:42][CH2:43][CH2:44][CH2:45][OH:46])=[O:36])[C:15](=[O:34])[N:16]3[CH2:19][CH2:20][CH2:21][N:22]([CH3:33])[C:23](=[O:24])[O:25][CH2:26][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[N:11][CH:10]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 258684-Amino-1-butanolHCID 69479908HCID 69479908, compound

Product 1

HCID 86612793HCID 86612793, compound

Procedure

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-[3-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 4-amino-1-butanol using conditions similar to Step 5 from Example 497 and obtained as a white solid: ES+ MS: 591 (M+H+).

Workup

  1. customobtained as a white solid

Sources & evidence

ORD record
ord-81213485bd0743eeaa4b64ad400fddde
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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