4-Morpholinecarbonyl chloride → HCID 69482092, compound

HRID 2364462Notes

Reaction equation

HRID 2364462 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[N:9][CH:10]=[C:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=2)[C:7]([OH:22])=[C:6]([C:23]([NH:25][CH2:26][CH2:27][N:28]2[CH2:32][CH2:31][NH:30][C:29]2=[O:33])=[O:24])[C:5]1=[O:34].[N:35]1([C:41](Cl)=[O:42])[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1>>[F:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][C:11]2[CH:12]=[C:13]3[C:8]([C:7]([OH:22])=[C:6]([C:23]([NH:25][CH2:26][CH2:27][N:28]4[CH2:32][CH2:31][NH:30][C:29]4=[O:33])=[O:24])[C:5](=[O:34])[N:4]3[CH2:3][CH2:2][NH:1][C:41]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[O:42])=[N:9][CH:10]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 69480462HCID 69480462, compound

Product 1

HCID 69482092HCID 69482092, compound

Procedure

This compound was prepared from 1-(2-aminoethyl)-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-N-[2-(2-oxo-1-imidazolidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxamide and 4-morpholinecarbonyl chloride employing methods similar to those described in Example 450 and was obtained as an orange solid: ES+ MS: 582 (M+H+).

Workup

  1. customwas obtained as an orange solid

Sources & evidence

ORD record
ord-b1dd6d5433a94e23bf89401f2199baad
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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