4-Morpholinecarbonyl chloride → HCID 69650856, compound

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Reaction Steps

This compound was prepared from 1-(2-aminoethyl)-7-[(4-fluorophenyl)methyl]-4-hydroxy-N-[2-(methyloxy)ethyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide and 4-morpholinecarbonyl chloride employing methods similar to those described in Example 450 and was obtained as an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.72 (s, 1 H), 3.13-3.20 (m, 3 H), 3.31 (s, 4 H), 3.45-3.50 (m, 5 H), 3.50-3.58 (m, 5 H), 4.13 (s, 2 H), 4.28 (t, J=6.39 Hz, 2 H), 6.77 (t, J=5.40 Hz, 1 H), 7.14 (t, J=8.84 Hz, 2 H), 7.41 (dd, J=8.49, 5.55 Hz, 2 H), 8.26 (s, 1 H), 8.55 (d, J=0.70 Hz, 1 H), 10.42 (t, J=5.62 Hz, 1 H); ES+ MS: 528 (M+H+).

Provenance & Evidence