4-Morpholinecarbonyl chloride → HCID 69482089, compound

HRID 2364464Notes

Reaction equation

HRID 2364464 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[N:9][CH:10]=[C:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=2)[C:7]([OH:22])=[C:6]([C:23]([NH:25][CH2:26][CH2:27][CH2:28][N:29]2[CH2:33][CH2:32][CH2:31][C:30]2=[O:34])=[O:24])[C:5]1=[O:35].[N:36]1([C:42](Cl)=[O:43])[CH2:41][CH2:40][O:39][CH2:38][CH2:37]1>>[F:21][C:18]1[CH:19]=[CH:20][C:15]([CH2:14][C:11]2[CH:12]=[C:13]3[C:8]([C:7]([OH:22])=[C:6]([C:23]([NH:25][CH2:26][CH2:27][CH2:28][N:29]4[CH2:33][CH2:32][CH2:31][C:30]4=[O:34])=[O:24])[C:5](=[O:35])[N:4]3[CH2:3][CH2:2][NH:1][C:42]([N:36]3[CH2:41][CH2:40][O:39][CH2:38][CH2:37]3)=[O:43])=[N:9][CH:10]=2)=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 69481013HCID 69481013, compound

Product 1

HCID 69482089HCID 69482089, compound

Procedure

This compound was prepared from 1-(2-aminoethyl)-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxamide and 4-morpholinecarbonyl chloride employing methods similar to those described in Example 450 and was obtained as an orange solid: ES+ MS: 595 (M+H+).

Workup

  1. customwas obtained as an orange solid

Sources & evidence

ORD record
ord-9427a837eaf2483da58abb41913a29d9
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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