4-Morpholinecarbonyl chloride → HCID 69482485, compound

HRID 2364465Notes

Reaction equation

HRID 2364465 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[N:9][CH:10]=[C:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=2)[C:7]([OH:22])=[C:6]([C:23]([NH:25][CH:26]([CH3:29])[CH2:27][OH:28])=[O:24])[C:5]1=[O:30].[N:31]1([C:37](Cl)=[O:38])[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[F:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][C:11]2[CH:12]=[C:13]3[C:8]([C:7]([OH:22])=[C:6]([C:23]([NH:25][CH:26]([CH3:29])[CH2:27][OH:28])=[O:24])[C:5](=[O:30])[N:4]3[CH2:3][CH2:2][NH:1][C:37]([N:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)=[O:38])=[N:9][CH:10]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 69482003HCID 69482003, compound

Product 1

HCID 69482485HCID 69482485, compound

Procedure

This compound was prepared from 1-(2-aminoethyl)-7-[(4-fluorophenyl)methyl]-4-hydroxy-N-(2-hydroxy-1-methylethyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide and 4-morpholinecarbonyl chloride employing methods similar to those described in Example 450 and was obtained as an orange solid: ES+ MS: 528 (M+H+).

Workup

  1. customwas obtained as an orange solid

Sources & evidence

ORD record
ord-e159d45094f94f2292bfc0bba1aa94ba
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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