4-Morpholinecarbonyl chloride → HCID 69482557, compound

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Reaction Steps

This compound was prepared from 1-(2-aminoethyl)-7-[(4-fluorophenyl)methyl]-4-hydroxy-N-[1-(hydroxymethyl)-2-methylpropyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide and 4-morpholinecarbonyl chloride employing methods similar to those described in Example 450 and was obtained as an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 0.88-0.96 (m, 6 H), 1.92-2.04 (m, 2 H), 3.12-3.21 (m, 4 H), 3.27-3.31 (m, 2 H), 3.44-3.51 (m, 5 H), 3.51-3.61 (m, 1 H), 3.86 (ddd, J=14.64, 5.30, 5.19 Hz, 1 H), 4.14 (s, 2 H), 4.29 (t, J=6.25 Hz, 2 H), 4.88 (t, J=5.05 Hz, 1 H), 6.77 (t, J=5.76 Hz, 1 H), 7.11-7.18 (m, 2 H), 7.39-7.45 (m, 2 H), 8.25 (d, J=1.54 Hz, 1 H), 8.54 (d, J=0.98 Hz, 1 H), 10.44 (d, J=9.13 Hz, 1 H); ES+ MS: 556 (M+H+).

Provenance & Evidence