4-Morpholinecarbonyl chloride → HCID 69481537, compound

Participants

Reaction Steps

This compound was prepared from 1-(2-aminoethyl)-7-[(4-fluorophenyl)methyl]-4-hydroxy-N-(2-hydroxy-1,1-dimethylethyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide and 4-morpholinecarbonyl chloride employing methods similar to those described in Example 450 and was obtained as an orange solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.36 (s, 6 H), 2.03 (s, 1 H), 3.13-3.20 (m, 4 H), 3.27-3.30 (m, 2 H), 3.48 (dt, J=4.56, 2.35 Hz, 6 H), 4.13 (s, 2 H), 4.27 (t, J=6.04 Hz, 2 H), 5.09-5.15 (m, 1 H), 6.75 (t, J=5.76 Hz, 1 H), 7.10-7.18 (m, 2.04 Hz, 2 H), 7.39-7.44 (m, 2 H), 8.23 (d, J=1.54 Hz, 1 H), 8.53 (d, J=1.26 Hz, 1 H), 10.53 (s, 1 H); ES+ MS: 542 (M+H+).

Provenance & Evidence