Ethanolamine → HCID 69482022, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxo-1-pyrrolidinyl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and ethanolamine employing methods similar to those described in Example 202 and was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ 10.36 (t, J=5.7 Hz, 1 H), 8.53 (s, 1 H), 7.41 (s, 1 H), 7.18 (dd, J=8.3, 5.5 Hz, 2 H), 7.03 (t, J=8.6 Hz, 2 H), 4.16-4.11 (m, 4 H), 3.85 (t, J=5.0 Hz, 2 H), 3.63 (m, 2 H), 3.38-3.33 (m, 4 H), 2.40 (t, J=8.0 Hz, 2 H), 2.03 (m, 2 H), 1.82 (m, 2 H); HRMS C25H27FN4O5 (M+H)+ calcd 483.2044, found 483.2046.

Provenance & Evidence