N-(2-Aminoethyl)ethyleneurea → HCID 69482685, compound

HRID 2364473Notes

Reaction equation

HRID 2364473 reaction equation
[F:1][C:2]1[CH:33]=[CH:32][C:5]([CH2:6][C:7]2[CH:16]=[C:15]3[C:10]([C:11]([OH:31])=[C:12]([C:26]([O:28]CC)=O)[C:13](=[O:25])[N:14]3[CH2:17][CH2:18][N:19]3[CH2:23][CH2:22][CH2:21][C:20]3=[O:24])=[N:9][CH:8]=2)=[CH:4][CH:3]=1.[NH2:34][CH2:35][CH2:36][N:37]1[CH2:41][CH2:40][NH:39][C:38]1=[O:42]>>[F:1][C:2]1[CH:33]=[CH:32][C:5]([CH2:6][C:7]2[CH:16]=[C:15]3[C:10]([C:11]([OH:31])=[C:12]([C:26]([NH:34][CH2:35][CH2:36][N:37]4[CH2:41][CH2:40][NH:39][C:38]4=[O:42])=[O:28])[C:13](=[O:25])[N:14]3[CH2:17][CH2:18][N:19]3[CH2:23][CH2:22][CH2:21][C:20]3=[O:24])=[N:9][CH:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 80480N-(2-Aminoethyl)ethyleneureaHCID 58882907Ethyl 7-(4-fluorobenzyl)-4-hydroxy-2-oxo-1-[2-oxopyrrolidin-1-yl ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate

Product 1

HCID 69482685HCID 69482685, compound

Procedure

This compound was prepared from ethyl 7-(4-fluorobenzyl)-4-hydroxy-2-oxo-1-[2-(2-oxopyrrolidin-1-yl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1-(2-aminoethyl)-2-imidazolidinone using conditions similar to those employed in Example 563 to provide a white solid: ES+ MS: 537 (M+H+).

Workup

  1. customto provide a white solid

Sources & evidence

ORD record
ord-b1d344b9f9cb47c78e907f70f1236ef7
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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