1-(3-Aminopropyl)-2-pyrrolidinone → HCID 69482728, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-(4-fluorobenzyl)-4-hydroxy-2-oxo-1-[2-(2-oxopyrrolidin-1-yl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1-(3-aminopropyl)-2-pyrrolidinone using conditions similar to those employed in Example 563 to provide a white solid: 1H NMR (d6-DMSO) δ 10.28 (1H, t, J=6 Hz), 8.55 (1H, s), 8.10 (1H, s), 7.40 (2H, dd, J=6, 9 Hz), 7.13 (2H, t, J=9 Hz), 4.37 (2H, t, J=6 Hz), 4.15 (2H, s), 3.43 (2H, t, J=6 Hz), 3.31-3.39 (6H, m), 3.22 (2H, t, J=7 Hz), 2.22 (2H, t, J=8 Hz), 1.87-2.00 (4H, m), 1.70-1.78 (4H, m); ES+ MS: 550 (M+H+).

Provenance & Evidence