2-Butanamine, 1-methoxy- → HCID 69482176, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-(4-fluorobenzyl)-4-hydroxy-2-oxo-1-[2-(2-oxopyrrolidin-1-yl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1-(methyloxy)-2-butanamine using conditions similar to those employed in Example 563 to provide a white solid: 1H NMR (d6-DMSO) δ 10.32 (1H, d, J=9 Hz), 8.53 (1H, s), 8.11 (1H, s), 7.38 (2H, dd, J=6, 9 Hz), 7.11 (2H, t, J=9 Hz), 4.37 (2H, b), 4.14 (2H, s), 4.05 (1H, b), 3.32-3.47 (6H, m), 3.26 (3H, s), 1.95 (2H, t, J=8 Hz), 1.69-1.80 (2H, m), 1.56-1.66 (1H, m), 1.42-1.56 (1H, m), 0.86 (3H, t, J=8 Hz); ES+ MS: 511 (M+H+).

Provenance & Evidence