Sodium Hydroxide → HCID 69481024, compound

Participants

Reaction Steps

In a manner similar to that described in example 474, from 7-[(4-fluorophenyl)methyl]-4-hydroxy-N-[(1S)-2-hydroxy-1-methylethyl]-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide (436 mg, 1.13 mmol described in example 359) and sodium hydroxide (1.08 mL of a 1 N solution) was prepared sodium 7-[(4-fluorophenyl)methyl]-3-({[(1S)-2-hydroxy-1-methylethyl]amino}carbonyl)-l -methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-4-olate (331 mg, 72% yield) as a white solid. 1H NMR (DMSO-d6) δ 10.41 (d, J=7.2 Hz, 1 H), 8.16 (s, 1 H), 7.59 (s, 1 H), 7.33-7.29 (m, 2 H), 7.11-7.07 (m, 2 H), 4.79 (m, 1 H), 3.93 (m, 1 H), 3.41 (m, 1 H), 3.28 (s, 3 H), 3.24 (m, 1 H), 1.03 (d, J=6.8 Hz, 3 H); MS m/z 386 (M+1).

Provenance & Evidence