1-Amino-2-propanol → HCID 69482008, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxo-1-pyrrolidinyl)propyl]-l ,2-dihydro-1,5-naphthyridine-3-carboxylate and 1-amino-2-propanol employing methods similar to those described in Example 202. 1H NMR (400 MHz, CDCl3) δ 10.36 (t, J=5.8 Hz, 1 H), 8.52 (s, 1 H), 7.38 (s, 1 H), 7.16 (dd, J=8.2, 5.5 Hz, 2 H), 7.01 (t, J=8.7 Hz, 2 H), 4.20-4.00 (m, 6 H), 3.60 (m, 1 H), 3.43-3.25 (m, 5 H), 2.39 (m, 2 H), 2.01 (m, 2 H), 1.80 (m, 2 H), 1.25 (d, J=6.4 Hz, 3 H); MS m/z 497 (M+H)+.

Provenance & Evidence