2-Methoxyethylamine → 7-[(4-Fluorophenyl)methyl]-4-hydroxy-N-[2-(methyloxy)ethyl]-2-oxo-1-[2-(2-oxo-1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxamide

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Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-(2-oxo-1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 2-(methyloxy)ethanamine using methods similar to Example 563 to provide a white solid: 1H NMR (CDCl3) δ 10.29 (1H, b), 8.54 (1H, s), 8.26 (1H, s), 7.24 (2H, dd, J=6, 9 Hz), 6.99 (2H, t, J=9 Hz), 4.39 (2H, t, J=8 Hz), 4.15 (2H, s), 3.50-3.69 (6H, m), 3.42 (3H, s), 3.36 (2H, b), 2.36 (2H, b), 1.75 (4H, b); ES+ MS: 497 (M+H+).

Provenance & Evidence