4-Amino-1-butanol → HCID 69481044, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-(2-oxo-1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 4-amino-1-butanol using methods similar to Example 563 to provide a white solid: 1H NMR (d6-DMSO) δ 10.28 (1H, t, J=7 Hz), 8.53 (1H, s), 8.17 (1H, s), 7.38 (2H, dd, J=6, 8 Hz), 7.11 (2H, t, J=9 Hz), 4.42 (1H, t, J=5 Hz), 4.36 (2H, t, J=5 Hz), 4.13 (2H, s), 3.47 (2H, t, J=7 Hz), 3.21-3.42 (6H, m), 2.00 (2H, t, J=6 Hz), 1.41-1.82 (8H, m); ES+ MS: 511 (M+H+).

Provenance & Evidence