(2R)-1-aminopropan-2-ol → HCID 69480339, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-(2-oxo-1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2R)-1-amino-2-propanol using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.10 (d, J=6.32 Hz, 3 H), 1.55-1.65 (m, 4 H), 2.04 (t, J=5.79 Hz, 2 H), 3.15-3.28 (m, 2 H), 3.40-3.53 (m, 4 H), 3.81 (br. s., 1 H), 4.16 (s, 2 H), 4.39 (t, J=6.42 Hz, 2 H), 4.95 (d, J=3.58 Hz, 1 H), 7.11-7.17 (m, 2 H), 7.38-7.43 (m, 2 H), 8.20 (d, J=1.47 Hz, 1 H), 8.56 (d, J=1.68 Hz, 1 H), 10.42 (t, J=5.16 Hz, 1 H), 17.23 (s, 1 H); ES+ MS: 497 (M+H+).

Provenance & Evidence