3-Amino-1-propanol → HCID 69482192, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-(2-oxo-1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 3-aminopropanol using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.09 (t, J=7.05 Hz, 2 H), 1.52-1.65 (m, 4 H), 1.65-1.75 (m, 2 H), 2.04 (t, J=6.42 Hz, 2 H), 3.26 (t, J=5.48 Hz, 2 H), 3.39-3.53 (m, 4 H), 4.16 (s, 2 H), 4.39 (t, J=6.42 Hz, 2 H), 4.55-4.63 (m, 1 H), 7.11-7.17 (m, 2 H), 7.38-7.43 (m, 2 H), 8.20 (s, 1 H), 8.56 (d, J=1.47 Hz, 1 H), 10.32 (t, J=5.58 Hz, 1 H), 17.25 (s, 1 H); ES+ MS: 497 (M+H+).

Provenance & Evidence