1-Amino-2-butanol → HCID 69480900, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-(2-oxo-1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1-amino-2-butanol using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 0.83-0.93 (m, 3 H), 1.38-1.45 (m, 2 H), 1.54-1.65 (m, 4 H), 2.04 (t, J=6.00 Hz, 2 H), 3.18-3.30 (m, 3 H), 3.44-3.57 (m, 4 H), 4.16 (s, 2 H), 4.31-4.45 (m, 2 H), 4.95 (d, J=5.26 Hz, 1 H), 7.11-7.18 (m, 2 H), 7.38-7.44 (m, 2 H), 8.20 (s, 1 H), 8.56 (d, J=1.68 Hz, 1 H), 10.42 (t, J=5.58 Hz, 1 H), 17.23 (s, 1 H); ES+ MS: 511 (M+H+).

Provenance & Evidence