(2R)-1-aminopropan-2-ol → HCID 69481003, compound

Participants

Reaction Steps

This compound was prepared from ethyl 1-{2-[acetyl(methyl)amino]ethyl}-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2R)-1-amino-2-propanol using methods similar to Example 574: step 2 to provide an off-white solid: 1H NMR (400 MHz, DMSO-d6@90° C.) δ ppm 1.14 (d, J=6.17 Hz, 3 H), 1.84 (s, 3 H), 2.91-2.98 (m, 3 H), 3.23-3.33 (m, 1 H), 3.40-3.50 (m, 1 H), 3.54 (t, J=6.72 Hz, 2 H), 3.85-3.88 (m, 1 H), 4.18 (s, 2 H), 4.37 (d, J=7.55 Hz, 2 H), 4.65 (d, J=5.90 Hz, 1 H), 7.12 (t, J=8.51 Hz, 2 H), 7.36-7.43 (m, 2 H), 8.07 (s, 1 H), 8.55 (s, 1 H), 10.35 (s, 1 H), 16.97-17.20 (m, 1 H); ES+ MS: 471 (M+H+).

Provenance & Evidence