L-Alaninol → HCID 69482010, compound

Participants

Reaction Steps

This compound was prepared from ethyl 1-{2-[acetyl(methyl)amino]ethyl}-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2S)-2-amino-1-propanol using methods similar to Example 574: step 2 to provide an off-white solid: 1H NMR (400 MHz, DMSO-d6@90° C.) δ ppm 1.23 (d, J=6.72 Hz, 3 H), 1.85 (s, 3 H), 2.95 (s, 2 H), 3.50-3.55 (m, 5 H), 4.07-4.12 (m, 1 H), 4.18 (s, 2 H), 4.36 (d, J=4.80 Hz, 2 H), 4.70 (t, J=5.63 Hz, 1 H), 7.12 (t, J=8.78 Hz, 2 H), 7.37-7.41 (m, 2 H), 8.08 (s, 1 H), 8.55 (s, 1 H), 10.27 (s, 1 H), 17.14 (s, 1 H); ES+ MS: 471 (M+H+).

Provenance & Evidence