2-Butanol, 4-amino- → HCID 69481490, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-(2-oxo-1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 4-amino-2-butanol using methods similar to Example 563 to provide a white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.06-1.12 (m, 3 H), 1.53-1.68 (m, 6 H), 2.04 (t, J=5.90 Hz, 2 H), 3.22-3.30 (m, 2 H), 3.48 (dt, J=13.48, 6.74 Hz, 4 H), 3.62-3.76 (m, 1 H), 4.16 (s, 2 H), 4.39 (t, J=6.21 Hz, 2 H), 4.64 (d, J=4.63 Hz, 1 H), 7.11-7.18 (m, 2 H), 7.38-7.44 (m, 2 H), 8.19 (s, 1 H), 8.56 (d, J=1.26 Hz, 1 H), 10.33 (t, J=5.48 Hz, 1 H), 17.27 (s, 1 H); ES+ MS: 511 (M+H+).

Provenance & Evidence