Sodium Hydroxide → HCID 69482287, compound

HRID 2364521Notes

Reaction equation

HRID 2364521 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[CH2:6][N:7]2[C:16]3[C:11](=[N:12][CH:13]=[C:14]([CH2:17][C:18]4[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=4)[CH:15]=3)[C:10]([OH:25])=[C:9]([C:26]([NH:28][CH3:29])=[O:27])[C:8]2=[O:30])[CH2:3][CH2:2]1.[OH-].[Na+:33]>>[CH:1]1([NH:4][C:5](=[O:31])[CH2:6][N:7]2[C:16]3[C:11](=[N:12][CH:13]=[C:14]([CH2:17][C:18]4[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=4)[CH:15]=3)[C:10]([O-:25])=[C:9]([C:26]([NH:28][CH3:29])=[O:27])[C:8]2=[O:30])[CH2:3][CH2:2]1.[Na+:33]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 69481082HCID 69481082, compound

Product 1

HCID 69482287HCID 69482287, compound

Procedure

This compound was prepared by treating a mixture of the product from Example 473 with 1.5 equivalents of 1N NaOH solution. The mixture was stirred 4 h at rt and filtered to afford the product as a white solid: 1H NMR (d6-DMSO) δ 10.15 (1H, br), 8.25 (1H, s), 7.69 (1H, br), 7.27 (3H, m), 7.08 (2H, t, J=9 Hz), 4.70 (2H, br s), 4.05 (2H, s), 2.79 (3H, d, J=5 Hz), 2.60 (1H, m), 0.61 (2H, m), 0.40 (2H, m).

Workup

  1. customThis compound was prepared
  2. additionby treating
  3. filtrationfiltered

Sources & evidence

ORD record
ord-34af7128afe147a890dc8e950bd6efb5
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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