Sodium Hydroxide → HCID 69480991, compound

Participants

Reaction Steps

In a manner similar to that described in example 474, from 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-[(1-methyl-1H-imidazol-2-yl)methyl]-N-[2-(methyloxy)ethyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide (506 mg, 1.09 mmol described in example 467) and 1 N sodium hydroxide (1.06 mL) was prepared sodium 7-[(4-fluorophenyl)methyl]-1-[(1-methyl-1H-imidazol-2-yl)methyl]-3-({[2-(methyloxy)ethyl]amino}carbonyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-4-olate (473 mg, 89% yield) as a white solid. 1H NMR (DMSO-d6) δ 10.72 (s, 1 H), 8.14 (s, 1 H), 7.92 (s, 1 H), 7.27-7.23 (m, 2 H), 7.08-7.03 (m, 2 H), 6.96 (s, 1 H), 6.71 (s, 1 H), 5.34 (s, 2 H), 3.94 (s, 2 H), 3.59 (s, 3 H), 3.38-3.33 (m, 4 H), 3.23 (s, 3 H); MS m/z 466 (M+1).

Provenance & Evidence