Sodium Hydroxide → HCID 69482132, compound

Participants

Reaction Steps

In a manner similar to that described in example 474, from 7-[(4-fluorophenyl)methyl]-4-hydroxy-N-(2-hydroxyethyl)-1-[(1-methyl-1H-imidazol-2-yl)methyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide (336 mg, 0.744 mmol described in example 468) and 1 N sodium hydroxide was prepared sodium 7-[(4-fluorophenyl)methyl]-3-{[(2-hydroxyethyl)amino]carbonyl}-1-[(1-methyl-1H-imidazol-2-yl)methyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-4-olate (324 mg, 92% yield) as a white solid. 1H NMR (DMSO-d6) δ 10.61 (s, 1 H), 8.16 (s, 1 H), 7.95 (s, 1 H), 7.27 (m, 2 H), 7.08 (m, 2 H), 6.98 (s, 1 H), 6.73 (s, 1 H), 5.36 (s, 2 H), 4.76 (br s, 1 H), 3.95 (s, 2 H), 3.62 (s, 3 H), 3.46 (br s, 2 H), 3.30 (br s, 2 H); MS m/z 452 (M+1).

Provenance & Evidence