(R)-(-)-2-Amino-1-propanol → HCID 69480464, compound

Participants

Reaction Steps

This compound was prepared from ethyl 1-{2-[acetyl(methyl)amino]ethyl}-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2R)-2-amino-1-propanol using methods similar to Example 574: step 2 to provide an off-white solid: 1H NMR (400 MHz, DMSO-d6@90° C.) δ ppm 1.23 (d, J=6.72 Hz, 3 H), 1.85 (s, 3 H), 2.80 (s, 1 H), 2.95 (s, 2 H), 3.50-3.55 (m, 4 H), 4.05-4.14 (m, 1 H), 4.18 (d, J=0.82 Hz, 2 H), 4.35 (s, 2 H), 4.70 (t, J=5.56 Hz, 1 H), 7.09-7.15 (m, 2 H), 7.36-7.42 (m, 2 H), 8.08 (s, 1 H), 8.55 (s, 1 H), 10.06-10.42 (m, 1 H), 17.06-17.18 (m, 1 H); ES− MS: 471 (M+H+).

Provenance & Evidence