Ethanolamine → HCID 69482154, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxo-1-piperidinyl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and ethanolamine using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.64-1.79 (m, 6 H), 2.19 (t, J=6.42 Hz, 2 H), 3.21 (t, J=5.58 Hz, 2 H), 3.33-3.48 (m, 4 H), 3.50-3.61 (m, 2 H), 4.15-4.25 (m, 4 H), 4.93 (t, J=5.05 Hz, 1 H), 7.10-7.18 (m, 2 H), 7.37-7.44 (m, 2 H), 8.00 (d, J=1.26 Hz, 1 H), 8.55 (d, J=1.26 Hz, 1 H), 10.41 (t, J=5.90 Hz, 1 H); ES+ MS: 497 (M+H+).

Provenance & Evidence