(2R)-1-aminopropan-2-ol → HCID 69480945, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxo-1-piperidinyl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2R)-1-amino-2-propanol using methods similar to Example 563 to provide a white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.09 (t, J=6.63 Hz, 3 H), 1.66-1.80 (m, 6 H), 2.19 (t, J=5.79 Hz, 2 H), 3.16-3.25 (m, 4 H), 3.34-3.48 (m, 2 H), 3.73-3.87 (m, 1 H), 4.17-4.24 (m, 4 H), 4.96 (d, J=4.63 Hz, 1 H), 7.11-7.17 (m, 2 H), 7.38-7.43 (m, 2 H), 8.00 (s, 1 H), 8.56 (s, 1 H), 10.43 (s, 1 H), 16.84 (s, 1 H); ES+ MS: 511 (M+H+).

Provenance & Evidence