(R)-(-)-2-Amino-1-propanol → HCID 69480134, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxo-1-piperidinyl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2R)-2-amino-1-propanol using methods similar to Example 563 to provide a tan solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.74 Hz, 3 H), 1.65-1.81 (m, 6 H), 2.19 (t, J=5.79 Hz, 2 H), 3.21 (t, J=5.90 Hz, 2 H), 3.37 (t, J=6.95 Hz, 2 H), 3.48 (t, J=5.05 Hz, 2 H), 4.05 (t, J=6.00 Hz, 1 H), 4.14-4.23 (m, 4 H), 5.00 (t, J=5.16 Hz, 1 H), 7.10-7.18 (m, 2 H), 7.37-7.44 (m, 2 H), 7.98 (s, 1 H), 8.56 (d, J=1.26 Hz, 1 H), 10.31-10.39 (m, 1 H), 17.24 (s, 1 H); ES+ MS: 511 (M+H+).

Provenance & Evidence