L-Alaninol → HCID 69482736, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxo-1-piperidinyl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2S)-2-amino-1-propanol using methods similar to Example 563 to provide a tan solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.74 Hz, 3 H), 1.65-1.80 (m, 6 H), 2.19 (t, J=5.79 Hz, 2 H), 3.21 (t, J=5.16 Hz, 2 H), 3.37 (t, J=7.79 Hz, 2 H), 3.48 (t, J=5.16 Hz, 2 H), 4.00-4.12 (m, 1 H), 4.16-4.28 (m, 4 H), 5.00 (t, J=5.16 Hz, 1 H), 7.11-7.18 (m, 2 H), 7.41 (dd, J=8.74, 5.58 Hz, 2 H), 7.99 (s, 1 H), 8.56 (d, J=1.47 Hz, 1 H), 10.37 (d, J=8.63 Hz, 1 H), 17.26 (s, 1 H); ES+ MS: 511 (M+H+).

Provenance & Evidence