3-Amino-1-propanol → HCID 69482074, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxo-1-piperidinyl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 3-amino-1-propanol using methods similar to Example 563 to provide a grey solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 1.69-1.79 (m, 8 H), 2.21 (t, J=6.31 Hz, 2 H), 2.82-2.87 (m, 1 H), 3.20-3.24 (m, 2 H), 3.37 (t, J=7.23 Hz, 2 H), 3.45-3.56 (m, 4 H), 4.17-4.25 (m, 3 H), 4.26-4.32 (m, 1 H), 7.09-7.15 (m, 2 H), 7.35-7.40 (m, 2 H), 7.86 (s, 1 H), 8.53 (s, 1 H), 10.29 (s, 1 H); ES+ MS: 511 (M+H+).

Provenance & Evidence