Methylamine → HCID 69482178, compound

Participants

Reaction Steps

In a similar manner to that described in example 196, from methyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-[4-(methyloxy)phenyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (50 mg, 0.115 mmol) and methylamine was prepared 7-[(4-fluorophenyl)methyl]-4-hydroxy-N-methyl-1-[4-(methyloxy)phenyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide (48 mg, 97% yield) as a white solid. 1H NMR (CDCl3) δ 9.96 (s, 1 H), 8.48 (s, 1 H), 7.11-7.05 (m, 4 H), 7.01-6.98 (m, 4 H), 6.77 (s, 1 H), 3.92 (s, 2 H), 3.87 (s, 3 H), 2.95 (d, J=4.8 Hz, 3 H); HRMS m/z calcd for C24H21FN3O4: 434.1511 Found: 434.1512.

Provenance & Evidence