2-Methoxyethylamine → HCID 69482463, compound

Participants

Reaction Steps

In a similar manner to that described in example 196, from methyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-[4-(methyloxy)phenyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (50 mg, 0.115 mmol) and [2-(methyloxy)ethyl]amine was prepared 7-[(4-fluorophenyl)methyl]-4-hydroxy-N-[2-(methyloxy)ethyl]-1-[4-(methyloxy)phenyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide (47 mg, 89% yield) as a white solid. 1H NMR (CDCl3) δ 10.14 (s, 1 H), 8.47 (s, 1 H), 7.12-7.04 (m, 4 H), 7.00-6.96 (m, 2 H), 6.93-6.89 (m, 2 H), 6.74 (s, 1 H), 3.91 (s, 2 H), 3.86 (s, 3 H), 3.59 (m, 2 H), 3.51 (m, 2 H), 3.31 (s, 3 H); HRMS m/z calcd for C26H25FN3O5: 478.1773. Found: 478.1773.

Provenance & Evidence