Ethyl 3-amino-5-(4-fluorobenzyl)picolinate → HCID 69480936, compound

Participants

Reaction Steps

This compound was prepared from ethyl 3-amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate and 3-(2-oxohexahydro-1H-azepin-1-yl)propanal using methods similar to Example 669: step 4 to provide a clear oil: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.28 (t, J=7.09 Hz, 3 H), 1.47-1.58 (m, 4 H), 1.58-1.74 (m, 4 H), 2.36-2.44 (m, 2 H), 3.15 (q, J=6.74 Hz, 2 H), 3.28-3.38 (m, 4 H), 3.94 (s, 2 H), 4.26 (q, J=7.07 Hz, 2 H), 7.07-7.16 (m, 3 H), 7.27-7.34 (m, 2 H), 7.62 (t, J=5.62 Hz, 1 H), 7.77 (d, J=1.82 Hz, 1 H); ES+ MS: 428 (M+H+).

Provenance & Evidence