(S)-(+)-1-Aminopropan-2-ol → HCID 69480910, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxohexahydro-1H-azepin-1-yl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2S)-1-amino-2-propanol using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.08-1.13 (m, 3 H), 1.55 (d, J=2.74 Hz, 4 H), 1.63 (s, 2 H), 1.65-1.78 (m, 2 H), 2.41 (d, J=10.11 Hz, 2 H), 3.19 (s, 1 H), 3.38 (d, J=6.95 Hz, 5 H), 3.81 (s, 1 H), 4.16-4.25 (m, 4 H), 4.96 (d, J=4.63 Hz, 1 H), 7.11-7.17 (m, 2 H), 7.38-7.44 (m, 2 H), 8.00 (s, 1 H), 8.56 (d, J=1.47 Hz, 1 H), 10.44 (t, J=6.21 Hz, 1 H), 17.21 (s, 1 H); ES+ MS: 525 (M+H+).

Provenance & Evidence