4-Amino-1-butanol → HCID 69482807, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxohexahydro-1 H-azepin-1-yl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 4-amino-1-butanol using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.25-1.85 (m, 12 H), 2.35-2.45 (m, 2 H), 3.40 (ddd, J=18.53, 12.53, 6.42 Hz, 8 H), 4.15-4.23 (m, 4 H), 4.44 (t, J=5.16 Hz, 1 H), 7.14 (t, J=8.95 Hz, 2 H), 7.37-7.43 (m, 2 H), 7.99 (s, 1 H), 8.56 (d, J=1.47 Hz, 1 H), 10.31 (t, J=6.11 Hz, 1 H), 17.21 (s, 1 H); ES+ MS: 539 (M+H+).

Provenance & Evidence