3-Amino-1-propanol → HCID 54706407, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxohexahydro-1H-azepin-1-yl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 3-amino-1-propanol using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.54 (d, J=4.42 Hz, 4 H), 1.60-1.76 (m, 6 H), 2.36-2.44 (m, 2 H), 3.33-3.39 (m, 4 H), 3.39-3.52 (m, 4 H), 4.15-4.24 (m, 4 H), 4.60 (t, J=5.05 Hz, 1 H), 7.14 (ddd, J=9.00, 6.69, 2.00 Hz, 2 H), 7.38-7.44 (m, 2 H), 7.99 (d, J=1.47 Hz, 1 H), 8.56 (d, J=1.47 Hz, 1 H), 10.33 (t, J=5.90 Hz, 1 H), 17.23 (s, 1 H); ES+ MS: 525 (M+H+).

Provenance & Evidence