(2R)-1-aminopropan-2-ol → HCID 69480479, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxohexahydro-1H-azepin-1-yl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2R)-1-amino-2-propanol using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.06-1.12 (m, 4 H), 1.54 (d, J=5.05 Hz, 4 H), 1.60-1.75 (m, 4 H), 2.36-2.45 (m, 2 H), 3.15-3.25 (m, 1 H), 3.32-3.47 (m, 4 H), 3.82 (ddd, J=10.84, 6.63, 4.42 Hz, 1 H), 4.15-4.24 (m, 4 H), 4.96 (d, J=4.84 Hz, 1 H) 7.10-7.18 (m, 2 H), 7.38-7.44 (m, 2 H), 8.00 (d, J=1.26 Hz, 1 H), 8.56 (d, J=1.47 Hz, 1 H), 10.44 (t, J=5.58 Hz, 1 H), 17.21 (s, 1 H); ES+ MS: 525 (M+H+).

Provenance & Evidence