3-Methoxypropylamine → HCID 69482157, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxohexahydro-1H-azepin-1-yl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and [3-(methyloxy)propyl]amine using methods similar to Example 563 to provide an orange solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.54 (d, J=3.58 Hz, 4 H), 1.64 (d, J=7.16 Hz, 2 H), 1.69-1.75 (m, 2 H), 1.77-1.82 (m, 2 H), 2.38-2.44 (m, 2 H), 3.24-3.26 (m, 3 H), 3.34-3.47 (m, 8 H), 4.15-4.25 (m, 4 H), 7.11-7.18 (m, 2 H), 7.40 (dd, J=8.63, 5.69 Hz, 2 H), 8.00 (s, 1 H), 8.56 (d, J=1.26 Hz, 1 H), 10.34 (t, J=5.90 Hz, 1 H), 17.19 (s, 1 H); ES+ MS: 539 (M+H+).

Provenance & Evidence