2-Butanol, 4-amino- → HCID 69482547, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxohexahydro-1H-azepin-1-yl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 4-amino-2-butanol using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.10 (d, J=6.32 Hz, 3 H), 1.37-1.87 (m, 10 H), 2.36-2.45 (m, 2 H), 3.32-3.48 (m, 5 H), 3.63-3.77 (m, 2 H), 4.12-4.23 (m, 4 H), 4.62 (br. s., 1 H), 7.14 (ddd, J=9.05, 6.63, 2.21 Hz, 2 H), 7.37-7.44 (m, 2 H), 7.99 (d, J=1.05 Hz, 1 H), 8.56 (d, J=1.26 Hz, 1 H), 10.35 (t, J=5.69 Hz, 1 H), 17.26 (s, 1 H); ES+ MS: 539 (M+H+).

Provenance & Evidence