L-Alaninol → HCID 69480418, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxohexahydro-1H-azepin-1-yl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2S)-2-amino-1-propanol using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.53 Hz, 3 H), 1.47-1.58 (m, 4 H), 1.61-1.74 (m, 4 H), 2.41 (d, J=11.58 Hz, 2 H), 3.38 (t, J=6.95 Hz, 4 H), 3.48 (t, J=5.05 Hz, 2 H), 3.97-4.12 (m, 1 H), 4.15-4.27 (m, 4 H), 4.98-5.02 (m, 1 H), 7.14 (t, J=8.95 Hz, 2 H), 7.41 (dd, J=8.84, 5.69 Hz, 2 H), 7.99 (s, 1 H), 8.56 (d, J=1.47 Hz, 1 H), 10.37 (d, J=8.00 Hz, 1 H), 17.24 (s, 1 H); ES+ MS: 525 (M+H+).

Provenance & Evidence