1-(3-Aminopropyl)-2-pyrrolidinone → HCID 69480456, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxohexahydro-1H-azepin-1-yl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1-(3-aminopropyl)-2-pyrrolidinone using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.54 (d, J=3.58 Hz, 4 H), 1.59-1.65 (m, 2 H), 1.65-1.81 (m, 4 H), 1.84-1.97 (m, 2 H), 2.21 (t, J=8.21 Hz, 2 H), 2.35-2.47 (m, 2 H), 3.24 (t, J=6.74 Hz, 2 H), 3.35 (td, J=7.05, 2.95 Hz, 8 H), 4.15-4.25 (m, 4 H), 7.14 (t, J=8.95 Hz, 2 H), 7.31-7.54 (m, 2 H), 8.00 (s, 1 H), 8.56 (d, J=1.47 Hz, 1 H), 10.31 (t, J=5.90 Hz, 1 H), 17.15 (s, 1 H); ES+ MS: 592 (M+H+).

Provenance & Evidence