Ethanolamine → HCID 54698996, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxohexahydro-1H-azepin-1-yl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and ethanolamine using methods similar to Example 563 to provide an off-white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.54 (d, J=5.05 Hz, 4 H), 1.60-1.75 (m, 4 H), 2.41 (d, J=11.16 Hz, 2 H), 3.34-3.42 (m, 4 H), 3.45 (t, J=5.58 Hz, 2 H), 3.53-3.63 (m, 2 H), 4.16-4.24 (m, 4 H), 4.93 (t, J=4.21 Hz, 1 H), 7.11-7.18 (m, 2 H), 7.37-7.45 (m, 2 H), 8.00 (s, 1 H), 8.56 (d, J=1.47 Hz, 1 H), 10.41 (t, J=6.00 Hz, 1 H), 17.20 (s, 1 H); ES+ MS: 511 (M+H+).

Provenance & Evidence