3-Fluoro-4-(methylcarbamoyl)benzeneboronic acid → Tert-butyl 3-(3-(3-fluoro-4-(methylcarbamoyl)phenyl)pyrazin-2-YL)azetidine-1-carboxylate

HRID 2364578ノート

反応式

HRID 2364578 の反応式
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[CH:6][C:7]=1[C:8](=[O:11])[NH:9][CH3:10].Cl[C:16]1[C:17]([CH:22]2[CH2:25][N:24]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:23]2)=[N:18][CH:19]=[CH:20][N:21]=1>>[F:1][C:2]1[CH:3]=[C:4]([C:16]2[C:17]([CH:22]3[CH2:23][N:24]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:25]3)=[N:18][CH:19]=[CH:20][N:21]=2)[CH:5]=[CH:6][C:7]=1[C:8](=[O:11])[NH:9][CH3:10]

参加物

3

反応物 2

HCID 447174673-Fluoro-4-(methylcarbamoyl)benzeneboronic acidHCID 59351411Tert-butyl 3-(3-chloropyrazin-2-yl)azetidine-1-carboxylate

生成物 1

HCID 86705405Tert-butyl 3-(3-(3-fluoro-4-(methylcarbamoyl)phenyl)pyrazin-2-YL)azetidine-1-carboxylate

実験手順

The compound was prepared analogously to Example 1 by using (3-fluoro-4-(methylcarbamoyl)phenyl)boronic acid (purchased from Combi Blocks) and tert-butyl 3-(3-chloropyrazin-2-yl)azetidine-1-carboxylate. m/z=287 (M+1-100).

後処理

  1. customThe compound was prepared analogously to Example 1

出典と根拠

ORDレコード
ord-1cb665e33047473ea464b608cd2c40e8
出典データセット
uspto-grants-2014_04
特許番号
US08691986B2

反応ノート

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