Sodium Chloride → 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-(1-methyl-piperidyl)-2,3-dihydrobenzofuran-4-carboxamide

Participants

Reaction Steps

7-[[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxylic acid 1q (300 mg, 0.68 mmol) and O-(benzotriazol-1-yl)-N,N,N′,N′-tetra methyluronium tetrafluoroborate (148 mg, 0.46 mmol) were dissolved in 30 mL of dichloromethane, followed by the addition of diisopropylethylamine (131 mg, 1 mmol). The reaction solution was stirred for 10 minutes followed by the addition of 1-methyl-piperidin-4-yl amine (52 mg, 0.46 mmol), and stirred for another 3 hours. The reaction mixture was added with 30 mL of saturated sodium chloride solution and 30 mL of dichloromethane successively, then seperated. The organic phase was washed with saturated sodium carbonate solution (50 mL×2), water (50 mL) and saturated sodium chloride solution (50 mL) successively, then dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain the title compound 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-(1-methyl-piperidyl)-2,3-dihydrobenzofuran-4-carboxamide 1 (194 mg, yield: 79%) as a white solid.

Provenance & Evidence