反应详情

温度

50 °C

Methyl 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,2-dimethyl-3H-benzofuran-4-carboxylate 4e (1.67 g, 3.48 mmol) was dissolved in 50 mL of methanol followed by the addition of 1 M lithium hydroxide solution (17.4 mL, 17.40 mmol). The reaction solution was heated to 50° C. and stirred for 12 hours. The resulting solution was added with 10 mL of water, and added dropwise with 1 M hydrochloric acid to adjust pH to 2 to 3. The reaction solution was concentrated under reduced pressure to obtain the title compound 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,2-dimethyl-3H-benzofuran-4-carboxylic acid 4f (1.89 g, yield: 100%) as a white solid.

1. concentrationThe reaction solution was concentrated under reduced pressure