反应详情

Tert-butyl piperazine-1-carboxylate 7a (7.44 g, 40 mmol) and (S)-2-chloromethyl-oxirane (3.70 g, 40 mmol) were dissolved in 60 mL of ethanol. The reaction solution was stirred for 12 hours. The resulting solution was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain the title compound tert-butyl 4-[[(2S)-oxiran-2-yl]methyl]piperazine-1-carboxylate 20a (9.20 g, yield: 95.0%) as a white solid.

1. concentrationThe resulting solution was concentrated under reduced pressure
2. customThe resulting residue was purified by silica gel column chromatography