benzyl N-[(2R)-2-hydroxy-3-(4-methylpiperazin-1-yl)propyl]carbamate → (2R)-1-amino-3-(4-methylpiperazin-1-yl)propan-2-ol

Participants

Reaction Steps

Benzyl N-[(2R)-2-hydroxy-3-(4-methylpiperazin-1-yl)propyl]carbamate 20d (830 mg, 2.70 mmol) was dissolved in 40 mL of methanol followed by the addition of palladium/carbon (85 mg, 10%), filled with hydrogen three times. The reaction solution was stirred for 12 hours and filtered. The filtrate was concentrated under reduced pressure to obtain the crude title compound (2R)-1-amino-3-(4-methylpiperazin-1-yl)propan-2-ol 20e (500 mg) as a light yellow oil, which was used in the next step without further furification.

Provenance & Evidence